High C1QTNF1 expression mediated by potential ncRNAs is associated with poor prognosis and tumor immunity in kidney renal clear cell carcinoma

Background: Kidney renal clear cell carcinoma (KIRC) originates from proximal tubular cells and is the most common subtype of carcinoma. KIRC characterized by changes in lipid metabolism, obesity a risk factor for it. C1q And TNF Related 1 (C1QTNF1), novel adipokine member TNF-related protein (CTRP) family, has been shown to affect progression various cancers. However, role C1QTNF1 not studied. Methods: The Wilcoxon rank sum test was used analyze expression tissues normal tissues. relationship between clinicopathological features levels also examined logistic regression test. In addition, effect on prognosis patients analyzed Kaplan-Meier (KM). Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) were potential signaling pathways biological functions differential genes. A nomogram constructed predict patients. Spearman correlation analysis performed determine association immune infiltration checkpoint upstream miRNAs lncRNAs predicted ENCORI online tool. Finally, we proliferation, invasion, migration abilities after knockdown. Results: significantly higher than Patients with had poor prognosis, finding supported survival analysis. correlated TNM pathologic stages, age, gender ( p < 0.05). level genes KIRC. Additionally, high associated stage I II, T1 T2, T3 T4, N0, M0 (HR > 1, calibration diagram shows that model effective predictive performance Knockdown inhibited migration, invasion. CYTOR AC040970.1/hsa-miR-27b-3p axis identified as likely ncRNA-related Conclusion: conclusion, our study suggests infiltration. increased